Current Therapies in Kidney Transplant Rejection
نویسندگان
چکیده
Despite significant advancements in immunosuppressive therapies, kidney transplant rejection continues to pose a substantial challenge, impacting the long-term survival of grafts. This article provides an overview diagnosis, current and management strategies for acute T-cell-mediated (TCMR) antibody-mediated (ABMR). TCMR is diagnosed through histological examination biopsy samples, which reveal infiltration mononuclear cells into allograft tissue. Corticosteroids serve as primary treatment TCMR, while severe or steroid-resistant cases may require T-cell-depleting agents, like Thymoglobulin. ABMR occurs due binding antibodies graft endothelial cells. The most common plasmapheresis, although its efficacy still subject debate. Other such intravenous immunoglobulins, anti-CD20 antibodies, complement inhibitors, proteasome are also utilized varying degrees, but their remains questionable. Management decisions depend on timing episode presence chronic changes. In managing both ABMR, it crucial optimize immunosuppression address adherence. However, further research needed explore newer therapeutics evaluate efficacy.
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ژورنال
عنوان ژورنال: Journal of Clinical Medicine
سال: 2023
ISSN: ['2077-0383']
DOI: https://doi.org/10.3390/jcm12154927